Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34

An inherited deficiency in the frataxin protein causes neurodegeneration of the dorsal root ganglia and Friedreich's ataxia (FA). Frataxin deficiency leads to oxidative stress and inflammatory changes in cell and animal models; however, the cause of the inflammatory changes, and especially what...

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Detalles Bibliográficos
Autores principales: Shen, Yan, McMackin, Marissa Z., Shan, Yuxi, Raetz, Alan, David, Sheila, Cortopassi, Gino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783034/
https://www.ncbi.nlm.nih.gov/pubmed/26954031
http://dx.doi.org/10.1371/journal.pone.0151026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783034/
https://www.ncbi.nlm.nih.gov/pubmed/26954031
http://dx.doi.org/10.1371/journal.pone.0151026

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