Principal Component Analysis of Multimodal Neuromelanin MRI and Dopamine Transporter PET Data Provides a Specific Metric for the Nigral Dopaminergic Neuronal Density

The loss of dopaminergic (DA) neurons in the substantia nigra (SN) is a major pathophysiological feature of patients with Parkinson's disease (PD). As nigral DA neurons contain both neuromelanin (NM) and dopamine transporter (DAT), decreased intensities in both NM-sensitive MRI and DAT PET refl...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Hiroshi, Shimada, Hitoshi, Kodaka, Fumitoshi, Suzuki, Masayuki, Shinotoh, Hitoshi, Hirano, Shigeki, Kershaw, Jeff, Inoue, Yuichi, Nakamura, Masaki, Sasai, Taeko, Kobayashi, Mina, Suhara, Tetsuya, Ito, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783074/
https://www.ncbi.nlm.nih.gov/pubmed/26954690
http://dx.doi.org/10.1371/journal.pone.0151191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783074/
https://www.ncbi.nlm.nih.gov/pubmed/26954690
http://dx.doi.org/10.1371/journal.pone.0151191

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