Interleukin‐21 administration to aged mice rejuvenates their peripheral T‐cell pool by triggering de novo thymopoiesis

The vaccination efficacy in the elderly is significantly reduced compared to younger populations due to thymic involution and age‐related intrinsic changes affecting their naïve T‐cell compartment. Interleukin (IL)‐21 was recently shown to display thymostimulatory properties. Therefore, we hypothesi...

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Detalles Bibliográficos
Autores principales: Al‐Chami, E., Tormo, A., Pasquin, S., Kanjarawi, R., Ziouani, S., Rafei, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783337/
https://www.ncbi.nlm.nih.gov/pubmed/26762709
http://dx.doi.org/10.1111/acel.12440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783337/
https://www.ncbi.nlm.nih.gov/pubmed/26762709
http://dx.doi.org/10.1111/acel.12440

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