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Absence of Tau triggers age‐dependent sciatic nerve morphofunctional deficits and motor impairment

Dementia is the cardinal feature of Alzheimer's disease (AD), yet the clinical symptoms of this disorder also include a marked loss of motor function. Tau abnormal hyperphosphorylation and malfunction are well‐established key events in AD neuropathology but the impact of the loss of normal Tau...

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Detalles Bibliográficos
Autores principales: Lopes, Sofia, Lopes, André, Pinto, Vítor, Guimarães, Marco R., Sardinha, Vanessa Morais, Duarte‐Silva, Sara, Pinheiro, Sara, Pizarro, João, Oliveira, João Filipe, Sousa, Nuno, Leite‐Almeida, Hugo, Sotiropoulos, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783352/
https://www.ncbi.nlm.nih.gov/pubmed/26748966
http://dx.doi.org/10.1111/acel.12391