Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington’s Disease

The principal projection neurons of the striatum are critically dependent on an afferent supply of brain derived neurotrophic factor (BDNF) for neurotrophic support. These neurons express TrkB, the cognate receptor for BDNF, which activates signaling pathways associated with neuronal survival and ph...

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Detalles Bibliográficos
Autores principales: Nguyen, Khanh Q., Rymar, Vladimir V., Sadikot, Abbas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783409/
https://www.ncbi.nlm.nih.gov/pubmed/27013968
http://dx.doi.org/10.3389/fncel.2016.00037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783409/
https://www.ncbi.nlm.nih.gov/pubmed/27013968
http://dx.doi.org/10.3389/fncel.2016.00037

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