Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia

The main objective of this study was to compare the physiological changes (withdrawal and corneal reflexes, respiratory and cardiac frequency, blood oxygen saturation, and rectal temperature) following intraperitoneal administration of ketamine (80 mg/kg) and xylazine (10 mg/kg) to 3-, 6-, 12- and 1...

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Detalles Bibliográficos
Autores principales: Giroux, Marie-Chantal, Santamaria, Raphael, Hélie, Pierre, Burns, Patrick, Beaudry, Francis, Vachon, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2015
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783652/
https://www.ncbi.nlm.nih.gov/pubmed/26489361
http://dx.doi.org/10.1538/expanim.15-0039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783652/
https://www.ncbi.nlm.nih.gov/pubmed/26489361
http://dx.doi.org/10.1538/expanim.15-0039

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