Cargando…

Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D(2) as Potential Anti-Leukemic Agents

Structurally similar double-point modified analogues of 1,25-dihydroxyvitamin D(2) (1,25D(2)) were screened in vitro for their pro-differentiating activity against the promyeloid cell line HL60. Their affinities towards human full length vitamin D receptor (VDR) and metabolic stability against human...

Descripción completa

Detalles Bibliográficos
Autores principales:	Corcoran, Aoife, Nadkarni, Sharmin, Yasuda, Kaori, Sakaki, Toshiyuki, Brown, Geoffrey, Kutner, Andrzej, Marcinkowska, Ewa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783874/ https://www.ncbi.nlm.nih.gov/pubmed/26840307 http://dx.doi.org/10.3390/ijms17020091

Ejemplares similares

Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D(2) Against Human Malignant Melanoma Cell Lines
por: Piotrowska, Anna, et al.
Publicado: (2016)

Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D(2) Derivatives Modified at the Side Chain and the A-Ring
por: Milczarek, Magdalena, et al.
Publicado: (2020)

Restored expression of vitamin D receptor and sensitivity to 1,25-dihydroxyvitamin D(3) in response to disrupted fusion FOP2–FGFR1 gene in acute myeloid leukemia cells
por: Marchwicka, Aleksandra, et al.
Publicado: (2016)

Immuno-Stimulating Activity of 1,25-Dihydroxyvitamin D in Blood Cells from Five Healthy People and in Blasts from Five Patients with Leukemias and Pre-Leukemic States
por: Marchwicka, Aleksandra, et al.
Publicado: (2023)

The Use of 1α,25-Dihydroxyvitamin D(3) as an Anticancer Agent
por: Marcinkowska, Ewa, et al.
Publicado: (2016)

Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D(3) and Identification of Their Metabolites
por: Mizumoto, Yuka, et al.
Publicado: (2023)

In Silico Prediction of the Metabolic Resistance of Vitamin D Analogs against CYP3A4 Metabolizing Enzyme
por: Żołek, Teresa, et al.
Publicado: (2022)

NADPH-Cytochrome P450 Reductase Is Regulated by All-Trans Retinoic Acid and by 1,25-Dihydroxyvitamin D(3) in Human Acute Myeloid Leukemia Cells
por: Gocek, Elżbieta, et al.
Publicado: (2014)

Perspectives of Differentiation Therapies of Acute Myeloid Leukemia: The Search for the Molecular Basis of Patients’ Variable Responses to 1,25-Dihydroxyvitamin D and Vitamin D Analogs
por: Marchwicka, Aleksandra, et al.
Publicado: (2014)

THU233 Reduction Of Overutilization Of 1,25-Dihydroxyvitamin D
por: Brown, Jeremy, et al.
Publicado: (2023)

MON-374 Management of 1,25-dihydroxyvitamin D (1,25-OHD) Mediated Hypercalcemia of Unknown Etiology
por: Menon, Sruthi, et al.
Publicado: (2020)

Serum 1,25-Dihydroxyvitamin D: An Outcome Prognosticator in Human Sepsis
por: Nguyen, H. Bryant, et al.
Publicado: (2013)

Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System
por: Faye, Pierre Antoine, et al.
Publicado: (2019)

Primary Human Osteoblasts in Response to 25-Hydroxyvitamin D(3), 1,25-Dihydroxyvitamin D(3) and 24R,25-Dihydroxyvitamin D(3)
por: van der Meijden, Karen, et al.
Publicado: (2014)

The Effect of Analogues of 1α,25-Dihydroxyvitamin D(2) on the Regrowth and Gene Expression of Human Colon Cancer Cells Refractory to 5-Fluorouracil
por: Neska, Jacek, et al.
Publicado: (2016)

Diverse Regulation of Vitamin D Receptor Gene Expression by 1,25-Dihydroxyvitamin D and ATRA in Murine and Human Blood Cells at Early Stages of Their Differentiation
por: Janik, Sylwia, et al.
Publicado: (2017)

Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D
por: Berkowska, Klaudia, et al.
Publicado: (2019)

Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D(3) Analogues and Their Stability to hCYP24A1-Dependent Catabolism
por: Kawagoe, Fumihiro, et al.
Publicado: (2021)

Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3
por: Halicka, H. Dorota, et al.
Publicado: (2012)

The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis
por: Rafique, Sara, et al.
Publicado: (2019)

Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis
por: Li, Chih-Huang, et al.
Publicado: (2019)

Antiproliferative Activity and in Vivo Toxicity of Double-Point Modified Analogs of 1,25-Dihydroxyergocalciferol
por: Trynda, Justyna, et al.
Publicado: (2015)

8-Cl-Adenosine enhances 1,25-dihydroxyvitamin D(3)-induced growth inhibition without affecting 1,25-dihydroxyvitamin D(3)-stimulated differentiation of primary mouse epidermal keratinocytes
por: Bollag, Wendy B, et al.
Publicado: (2004)

25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D, and Peripheral Bone Densitometry in Adults with Celiac Disease
por: Ciacci, Carolina, et al.
Publicado: (2020)

Characteristics of Serum Ratios of 1,25-Dihydroxyvitamin D to 25-Hydroxyvitamin D for Assessment of Bone Metabolism
por: Yamamoto, Koichiro, et al.
Publicado: (2021)

1,25-dihydroxyvitamin D and PTHrP mediated malignant hypercalcemia in a seminoma
por: Rodríguez-Gutiérrez, René, et al.
Publicado: (2014)

Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint
por: Jeffery, Louisa E., et al.
Publicado: (2018)

Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy
por: Zeng, Xiaoyun, et al.
Publicado: (2017)

SAT-356 Reversible Suppression of Serum 1,25-Dihydroxyvitamin D in Williams Syndrome
por: Torchinsky, Michael Yuri, et al.
Publicado: (2020)

Severe Hypercalcemia From Inhalation Pneumonitis via Activation of 1,25 Dihydroxyvitamin D
por: Rosenstein, Kyle, et al.
Publicado: (2022)

1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells
por: Jiang, Yijie, et al.
Publicado: (2023)

1,25-Dihydroxyvitamin D(3) regulates furin-mediated FGF23 cleavage
por: Xie, Han, et al.
Publicado: (2023)

Kidney disease and vitamin D levels: 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and VDR activation
por: Dusso, Adriana S
Publicado: (2011)

25-Hydroxyvitamin D(3) and 1,25-Dihydroxyvitamin D(3) Promote the Differentiation of Human Subcutaneous Preadipocytes
por: Nimitphong, Hataikarn, et al.
Publicado: (2012)

Familial vitamin D resistant rickets: End-organ resistance to 1,25-dihydroxyvitamin D
por: Choudhury, Sangita, et al.
Publicado: (2013)

Synergy of 1,25-dihydroxyvitamin D3 and carboplatin in growth suppression of SKOV-3 cells
por: ZHANG, ZENGLI, et al.
Publicado: (2014)

1,25-Dihydroxyvitamin D(3) Inhibits Podocyte uPAR Expression and Reduces Proteinuria
por: Ma, Jianchao, et al.
Publicado: (2013)

1,25-Dihydroxyvitamin-D(3) Induces Avian β-Defensin Gene Expression in Chickens
por: Zhang, Long, et al.
Publicado: (2016)

The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D(3)-Resistant Rickets
por: Akıncı, Ayşehan, et al.
Publicado: (2017)

Downregulation of Runx2 by 1,25-Dihydroxyvitamin D(3) Induces the Transdifferentiation of Osteoblasts to Adipocytes
por: Kim, Jung Ha, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fqs4htfe4u3b9ia70751e2rkfd