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Can follicular helper T cells be targeted to improve vaccine efficacy?

The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of long-lived antibody-secreting plasma cells. The size and quality of the GC respo...

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Detalles Bibliográficos
Autores principales: Linterman, Michelle A., Hill, Danika L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784016/
https://www.ncbi.nlm.nih.gov/pubmed/26989476
http://dx.doi.org/10.12688/f1000research.7388.1
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author Linterman, Michelle A.
Hill, Danika L.
author_facet Linterman, Michelle A.
Hill, Danika L.
author_sort Linterman, Michelle A.
collection PubMed
description The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of long-lived antibody-secreting plasma cells. The size and quality of the GC response are directed by a specialised subset of CD4 (+) T cells: T follicular helper (Tfh) cells. Tfh cells provide growth and differentiation signals to GC B cells and mediate positive selection of high-affinity B cell clones in the GC, thereby determining which B cells exit the GC as plasma cells and memory B cells. Because of their central role in the production of long-lasting humoral immunity, Tfh cells represent an interesting target for rational vaccine design.
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spelling pubmed-47840162016-03-16 Can follicular helper T cells be targeted to improve vaccine efficacy? Linterman, Michelle A. Hill, Danika L. F1000Res Review The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of long-lived antibody-secreting plasma cells. The size and quality of the GC response are directed by a specialised subset of CD4 (+) T cells: T follicular helper (Tfh) cells. Tfh cells provide growth and differentiation signals to GC B cells and mediate positive selection of high-affinity B cell clones in the GC, thereby determining which B cells exit the GC as plasma cells and memory B cells. Because of their central role in the production of long-lasting humoral immunity, Tfh cells represent an interesting target for rational vaccine design. F1000Research 2016-01-20 /pmc/articles/PMC4784016/ /pubmed/26989476 http://dx.doi.org/10.12688/f1000research.7388.1 Text en Copyright: © 2016 Linterman MA and Hill DL http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Linterman, Michelle A.
Hill, Danika L.
Can follicular helper T cells be targeted to improve vaccine efficacy?
title Can follicular helper T cells be targeted to improve vaccine efficacy?
title_full Can follicular helper T cells be targeted to improve vaccine efficacy?
title_fullStr Can follicular helper T cells be targeted to improve vaccine efficacy?
title_full_unstemmed Can follicular helper T cells be targeted to improve vaccine efficacy?
title_short Can follicular helper T cells be targeted to improve vaccine efficacy?
title_sort can follicular helper t cells be targeted to improve vaccine efficacy?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784016/
https://www.ncbi.nlm.nih.gov/pubmed/26989476
http://dx.doi.org/10.12688/f1000research.7388.1
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