GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

BACKGROUND: Alpha-tocopheryloxyacetic acid (α-TEA) is a semi-synthetic derivative of naturally occurring vitamin E (alpha-tocopherol) that can be delivered via an oral route. Preclinical in vitro and in vivo data demonstrated that α-TEA is a potent anti-tumor agent with a safe toxicity profile in mi...

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Detalles Bibliográficos
Autores principales: Guerrouahen, Bella S., Hahn, Tobias, Alderman, Zefora, Curti, Brendan, Urba, Walter, Akporiaye, Emmanuel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784284/
https://www.ncbi.nlm.nih.gov/pubmed/26957307
http://dx.doi.org/10.1186/s12885-016-2220-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784284/
https://www.ncbi.nlm.nih.gov/pubmed/26957307
http://dx.doi.org/10.1186/s12885-016-2220-6

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