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Sort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relations
BACKGROUND: Sort-seq is an effective approach for simultaneous activity measurements in a large-scale library, combining flow cytometry, deep sequencing, and statistical inference. Such assays enable the characterization of functional landscapes at unprecedented scale for a wide-reaching array of bi...
Autores principales: | Peterman, Neil, Levine, Erel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784318/ https://www.ncbi.nlm.nih.gov/pubmed/26956374 http://dx.doi.org/10.1186/s12864-016-2533-5 |
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