A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells

Signalling through gap junctions contributes to control insulin secretion and, thus, blood glucose levels. Gap junctions of the insulin-producing β-cells are made of connexin 36 (Cx36), which is encoded by the GJD2 gene. Cx36-null mice feature alterations mimicking those observed in type 2 diabetes...

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Detalles Bibliográficos
Autores principales: Cigliola, Valentina, Populaire, Celine, Pierri, Ciro L., Deutsch, Samuel, Haefliger, Jacques-Antoine, Fadista, João, Lyssenko, Valeriya, Groop, Leif, Rueedi, Rico, Thorel, Fabrizio, Herrera, Pedro Luis, Meda, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784816/
https://www.ncbi.nlm.nih.gov/pubmed/26959991
http://dx.doi.org/10.1371/journal.pone.0150880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784816/
https://www.ncbi.nlm.nih.gov/pubmed/26959991
http://dx.doi.org/10.1371/journal.pone.0150880

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