Cargando…

A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells

Signalling through gap junctions contributes to control insulin secretion and, thus, blood glucose levels. Gap junctions of the insulin-producing β-cells are made of connexin 36 (Cx36), which is encoded by the GJD2 gene. Cx36-null mice feature alterations mimicking those observed in type 2 diabetes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cigliola, Valentina, Populaire, Celine, Pierri, Ciro L., Deutsch, Samuel, Haefliger, Jacques-Antoine, Fadista, João, Lyssenko, Valeriya, Groop, Leif, Rueedi, Rico, Thorel, Fabrizio, Herrera, Pedro Luis, Meda, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784816/ https://www.ncbi.nlm.nih.gov/pubmed/26959991 http://dx.doi.org/10.1371/journal.pone.0150880

Ejemplares similares

Association of CX36 Protein Encoding Gene GJD2 with Refractive Errors
por: Kunceviciene, Edita, et al.
Publicado: (2022)

Altered Expression of GJD2 Messenger RNA and the Coded Protein Connexin 36 in Negative Lens–induced Myopia of Guinea Pigs
por: Zhu, Qiurong, et al.
Publicado: (2020)

The Role of GJD2(Cx36) in Refractive Error Development
por: van der Sande, Emilie, et al.
Publicado: (2022)

Decreased expression of gap junction delta-2 (GJD2) messenger RNA and connexin 36 protein in form-deprivation myopia of guinea pigs
por: Yang, Guo-Yuan, et al.
Publicado: (2019)

Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel
por: Lee, Seu-Na, et al.
Publicado: (2023)

Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
por: Parikh, Hemang, et al.
Publicado: (2009)

Reduction of Connexin36 Content by ICER-1 Contributes to Insulin-Secreting Cells Apoptosis Induced by Oxidized LDL Particles
por: Haefliger, Jacques-Antoine, et al.
Publicado: (2013)

Authors' Reply
por: Lyssenko, Valeriya, et al.
Publicado: (2006)

Targeting Endothelial Connexin37 Reduces Angiogenesis and Decreases Tumor Growth
por: Sathiyanadan, Karthik, et al.
Publicado: (2022)

Phenotypic Consequences of the GJD2 Risk Genotype in Myopia Development
por: Haarman, Annechien E. G., et al.
Publicado: (2021)

Targeting endothelial connexin40 inhibits tumor growth by reducing angiogenesis and improving vessel perfusion
por: Alonso, Florian, et al.
Publicado: (2016)

Variants in the FFAR1 Gene Are Associated with Beta Cell Function
por: Kalis, Martins, et al.
Publicado: (2007)

Fasting Versus Postload Plasma Glucose Concentration and the Risk for Future Type 2 Diabetes: Results from the Botnia Study
por: Abdul-Ghani, Muhammad A., et al.
Publicado: (2009)

GJD Modulates Cardiac/Vascular Inflammation and Decreases Blood Pressure in Hypertensive Rats
por: Mohammed, Shadi A. D., et al.
Publicado: (2022)

Connexin37‐Dependent Mechanisms Selectively Contribute to Modulate Angiotensin II‐Mediated Hypertension
por: Le Gal, Loïc, et al.
Publicado: (2019)

Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release
por: Meens, Merlijn J, et al.
Publicado: (2015)

Structural and Functional Consequences of Connexin 36 (Cx36) Interaction with Calmodulin
por: Siu, Ryan C. F., et al.
Publicado: (2016)

A Variant in the KCNQ1 Gene Predicts Future Type 2 Diabetes and Mediates Impaired Insulin Secretion
por: Jonsson, Anna, et al.
Publicado: (2009)

GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population
por: Lundgren, Virve M., et al.
Publicado: (2010)

Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition
por: Bhattacharyya, Samadrita, et al.
Publicado: (2019)

Antihypertensive, antioxidant, and renal protective impact of integrated GJD with captopril in spontaneously hypertensive rats
por: Mohammed, Shadi A. D., et al.
Publicado: (2023)

Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy
por: Motaghi, Sahel, et al.
Publicado: (2017)

Genetic Prediction of Future Type 2 Diabetes
por: Lyssenko, Valeriya, et al.
Publicado: (2005)

Previously Associated Type 2 Diabetes Variants May Interact With Physical Activity to Modify the Risk of Impaired Glucose Regulation and Type 2 Diabetes: A Study of 16,003 Swedish Adults
por: Brito, Ema C., et al.
Publicado: (2009)

Minimal Contribution of Fasting Hyperglycemia to the Incidence of Type 2 Diabetes in Subjects With Normal 2-h Plasma Glucose
por: Abdul-Ghani, Muhammad A., et al.
Publicado: (2010)

Endocytosis of Connexin 36 is Mediated by Interaction with Caveolin-1
por: Kotova, Anna, et al.
Publicado: (2020)

Sources of Calcium at Connexin 36 Gap Junctions in the Retina
por: Lee, Yuan-Hao, et al.
Publicado: (2023)

Author Correction: Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition
por: Bhattacharyya, Samadrita, et al.
Publicado: (2020)

Extensive GJD2 Expression in the Song Motor Pathway Reveals the Extent of Electrical Synapses in the Songbird Brain
por: Alcami, Pepe, et al.
Publicado: (2021)

Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
por: Quint, Wim H., et al.
Publicado: (2021)

Colocalization of connexin 36 and corticotropin-releasing hormone in the mouse brain
por: Westberg, Lars, et al.
Publicado: (2009)

Connexin-36 distribution and layer-specific topography in the cat retina
por: Telkes, Ildikó, et al.
Publicado: (2019)

Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons
por: Sitaraman, Sahana, et al.
Publicado: (2021)

Differential Expression of BOC, SPOCK2, and GJD3 Is Associated with Brain Metastasis of ER-Negative Breast Cancers
por: Pedrosa, Rute M. S. M., et al.
Publicado: (2021)

Connexin36 Expression in the Mammalian Retina: A Multiple-Species Comparison
por: Kovács-Öller, Tamás, et al.
Publicado: (2017)

Intralumenal docking of connexin 36 channels in the ER isolates mistrafficked protein
por: Tetenborg, Stephan, et al.
Publicado: (2023)

Connexin43 Inhibition Prevents Human Vein Grafts Intimal Hyperplasia
por: Longchamp, Alban, et al.
Publicado: (2015)

Variation in GYS1 Interacts with Exercise and Gender to Predict Cardiovascular Mortality
por: Fredriksson, Jenny, et al.
Publicado: (2007)

The In Vivo β-to-β-Cell Chat Room: Connexin Connections Matter
por: Meda, Paolo
Publicado: (2012)

Effects of Common Genetic Variants Associated With Type 2 Diabetes and Glycemic Traits on α- and β-Cell Function and Insulin Action in Humans
por: Jonsson, Anna, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ovb2dqbr1csb61iip9u43o8v39