Delayed emergence of subdiffractionsized mutant huntingtin fibrils following inclusion body formation

Aberrant aggregation of improperly folded proteins is the hallmark of several human neurodegenerative disorders, including Huntington’s Disease (HD) with autosomal-dominant inheritance. In HD, expansion of the CAG-repeat-encoded polyglutamine (polyQ) stretch beyond ~40 glutamines in huntingtin (Htt)...

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Detalles Bibliográficos
Autores principales: Sahl, Steffen J., Lau, Lana, Vonk, Willianne I. M., Weiss, Lucien E., Frydman, Judith, Moerner, W. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785097/
https://www.ncbi.nlm.nih.gov/pubmed/26350150
http://dx.doi.org/10.1017/S0033583515000219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785097/
https://www.ncbi.nlm.nih.gov/pubmed/26350150
http://dx.doi.org/10.1017/S0033583515000219

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