Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

Neurodegenerative diseases (NDs) are often associated with the presence of misfolded protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and muscle structures affected during NDs progression. HSPB8 exerts a potent pro-degradative activity on several misfolded proteins res...

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Detalles Bibliográficos
Autores principales: Crippa, Valeria, D’Agostino, Vito G., Cristofani, Riccardo, Rusmini, Paola, Cicardi, Maria E., Messi, Elio, Loffredo, Rosa, Pancher, Michael, Piccolella, Margherita, Galbiati, Mariarita, Meroni, Marco, Cereda, Cristina, Carra, Serena, Provenzani, Alessandro, Poletti, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785366/
https://www.ncbi.nlm.nih.gov/pubmed/26961006
http://dx.doi.org/10.1038/srep22827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785366/
https://www.ncbi.nlm.nih.gov/pubmed/26961006
http://dx.doi.org/10.1038/srep22827

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