Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative

Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acut...

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Autores principales: Page, Kimberly, Mirzazadeh, Ali, Rice, Thomas M., Grebely, Jason, Kim, Arthur Y., Cox, Andrea L., Morris, Meghan D., Hellard, Margaret, Bruneau, Julie, Shoukry, Naglaa H., Dore, Gregory J., Maher, Lisa, Lloyd, Andrew R., Lauer, Georg, Prins, Maria, McGovern, Barbara H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785397/
https://www.ncbi.nlm.nih.gov/pubmed/26973850
http://dx.doi.org/10.1093/ofid/ofw024
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author Page, Kimberly
Mirzazadeh, Ali
Rice, Thomas M.
Grebely, Jason
Kim, Arthur Y.
Cox, Andrea L.
Morris, Meghan D.
Hellard, Margaret
Bruneau, Julie
Shoukry, Naglaa H.
Dore, Gregory J.
Maher, Lisa
Lloyd, Andrew R.
Lauer, Georg
Prins, Maria
McGovern, Barbara H.
author_facet Page, Kimberly
Mirzazadeh, Ali
Rice, Thomas M.
Grebely, Jason
Kim, Arthur Y.
Cox, Andrea L.
Morris, Meghan D.
Hellard, Margaret
Bruneau, Julie
Shoukry, Naglaa H.
Dore, Gregory J.
Maher, Lisa
Lloyd, Andrew R.
Lauer, Georg
Prins, Maria
McGovern, Barbara H.
author_sort Page, Kimberly
collection PubMed
description Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.
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spelling pubmed-47853972016-03-11 Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative Page, Kimberly Mirzazadeh, Ali Rice, Thomas M. Grebely, Jason Kim, Arthur Y. Cox, Andrea L. Morris, Meghan D. Hellard, Margaret Bruneau, Julie Shoukry, Naglaa H. Dore, Gregory J. Maher, Lisa Lloyd, Andrew R. Lauer, Georg Prins, Maria McGovern, Barbara H. Open Forum Infect Dis Brief Reports Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease. Oxford University Press 2016-02-08 /pmc/articles/PMC4785397/ /pubmed/26973850 http://dx.doi.org/10.1093/ofid/ofw024 Text en Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Page, Kimberly
Mirzazadeh, Ali
Rice, Thomas M.
Grebely, Jason
Kim, Arthur Y.
Cox, Andrea L.
Morris, Meghan D.
Hellard, Margaret
Bruneau, Julie
Shoukry, Naglaa H.
Dore, Gregory J.
Maher, Lisa
Lloyd, Andrew R.
Lauer, Georg
Prins, Maria
McGovern, Barbara H.
Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative
title Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative
title_full Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative
title_fullStr Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative
title_full_unstemmed Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative
title_short Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative
title_sort interferon lambda 4 genotype is associated with jaundice and elevated aminotransferase levels during acute hepatitis c virus infection: findings from the inc3 collaborative
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785397/
https://www.ncbi.nlm.nih.gov/pubmed/26973850
http://dx.doi.org/10.1093/ofid/ofw024
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