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Reduction Impairs the Antibacterial Activity but Benefits the LPS Neutralization Ability of Human Enteric Defensin 5
Oxidized human defensin 5 (HD5(OX)), a Paneth cell-secreted antibacterial peptide with three characteristic disulfide bonds, protects the host from invasion by morbigenous microbes in the small intestine. HD5(OX) can be reduced by thioredoxin (Trx) in vitro, while the biochemical properties of the r...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785407/ https://www.ncbi.nlm.nih.gov/pubmed/26960718 http://dx.doi.org/10.1038/srep22875 |