Reduction Impairs the Antibacterial Activity but Benefits the LPS Neutralization Ability of Human Enteric Defensin 5

Oxidized human defensin 5 (HD5(OX)), a Paneth cell-secreted antibacterial peptide with three characteristic disulfide bonds, protects the host from invasion by morbigenous microbes in the small intestine. HD5(OX) can be reduced by thioredoxin (Trx) in vitro, while the biochemical properties of the r...

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Detalles Bibliográficos
Autores principales: Wang, Cheng, Shen, Mingqiang, Zhang, Naixin, Wang, Song, Xu, Yang, Chen, Shilei, Chen, Fang, Yang, Ke, He, Ting, Wang, Aiping, Su, Yongping, Cheng, Tianmin, Zhao, Jinghong, Wang, Junping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785407/
https://www.ncbi.nlm.nih.gov/pubmed/26960718
http://dx.doi.org/10.1038/srep22875

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