Cargando…
Metabolic stressors disrupt proteome homeostasis to suppress malignancy
Within tumor cells the heat shock factor 1 (HSF1)-mediated stress response is constitutively mobilized to counter persistent proteotoxic stress, thus sustaining their fragile proteome homeostasis and supporting robust malignant phenotypes. Intriguingly, our new studies reveal that metabolic stressor...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786015/ https://www.ncbi.nlm.nih.gov/pubmed/26973866 http://dx.doi.org/10.1080/23723556.2014.1002718 |