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Metabolic stressors disrupt proteome homeostasis to suppress malignancy

Within tumor cells the heat shock factor 1 (HSF1)-mediated stress response is constitutively mobilized to counter persistent proteotoxic stress, thus sustaining their fragile proteome homeostasis and supporting robust malignant phenotypes. Intriguingly, our new studies reveal that metabolic stressor...

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Detalles Bibliográficos
Autor principal: Dai, Chengkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786015/
https://www.ncbi.nlm.nih.gov/pubmed/26973866
http://dx.doi.org/10.1080/23723556.2014.1002718