Metabolic stressors disrupt proteome homeostasis to suppress malignancy

Within tumor cells the heat shock factor 1 (HSF1)-mediated stress response is constitutively mobilized to counter persistent proteotoxic stress, thus sustaining their fragile proteome homeostasis and supporting robust malignant phenotypes. Intriguingly, our new studies reveal that metabolic stressor...

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Detalles Bibliográficos
Autor principal: Dai, Chengkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786015/
https://www.ncbi.nlm.nih.gov/pubmed/26973866
http://dx.doi.org/10.1080/23723556.2014.1002718
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author Dai, Chengkai
author_facet Dai, Chengkai
author_sort Dai, Chengkai
collection PubMed
description Within tumor cells the heat shock factor 1 (HSF1)-mediated stress response is constitutively mobilized to counter persistent proteotoxic stress, thus sustaining their fragile proteome homeostasis and supporting robust malignant phenotypes. Intriguingly, our new studies reveal that metabolic stressors, such as metformin, inactivate HSF1 and provoke proteomic chaos, thereby impeding tumorigenesis.
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spelling pubmed-47860152016-03-10 Metabolic stressors disrupt proteome homeostasis to suppress malignancy Dai, Chengkai Mol Cell Oncol Author's View Within tumor cells the heat shock factor 1 (HSF1)-mediated stress response is constitutively mobilized to counter persistent proteotoxic stress, thus sustaining their fragile proteome homeostasis and supporting robust malignant phenotypes. Intriguingly, our new studies reveal that metabolic stressors, such as metformin, inactivate HSF1 and provoke proteomic chaos, thereby impeding tumorigenesis. Taylor & Francis 2015-01-23 /pmc/articles/PMC4786015/ /pubmed/26973866 http://dx.doi.org/10.1080/23723556.2014.1002718 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Dai, Chengkai
Metabolic stressors disrupt proteome homeostasis to suppress malignancy
title Metabolic stressors disrupt proteome homeostasis to suppress malignancy
title_full Metabolic stressors disrupt proteome homeostasis to suppress malignancy
title_fullStr Metabolic stressors disrupt proteome homeostasis to suppress malignancy
title_full_unstemmed Metabolic stressors disrupt proteome homeostasis to suppress malignancy
title_short Metabolic stressors disrupt proteome homeostasis to suppress malignancy
title_sort metabolic stressors disrupt proteome homeostasis to suppress malignancy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786015/
https://www.ncbi.nlm.nih.gov/pubmed/26973866
http://dx.doi.org/10.1080/23723556.2014.1002718
work_keys_str_mv AT daichengkai metabolicstressorsdisruptproteomehomeostasistosuppressmalignancy

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