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Metabolic stressors disrupt proteome homeostasis to suppress malignancy
Within tumor cells the heat shock factor 1 (HSF1)-mediated stress response is constitutively mobilized to counter persistent proteotoxic stress, thus sustaining their fragile proteome homeostasis and supporting robust malignant phenotypes. Intriguingly, our new studies reveal that metabolic stressor...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786015/ https://www.ncbi.nlm.nih.gov/pubmed/26973866 http://dx.doi.org/10.1080/23723556.2014.1002718 |