Quantitative Trait Locus Based Virulence Determinant Mapping of the HSV-1 Genome in Murine Ocular Infection: Genes Involved in Viral Regulatory and Innate Immune Networks Contribute to Virulence

Herpes simplex virus type 1 causes mucocutaneous lesions, and is the leading cause of infectious blindness in the United States. Animal studies have shown that the severity of HSV-1 ocular disease is influenced by three main factors; innate immunity, host immune response and viral strain. We previou...

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Detalles Bibliográficos
Autores principales: Kolb, Aaron W., Lee, Kyubin, Larsen, Inna, Craven, Mark, Brandt, Curtis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786273/
https://www.ncbi.nlm.nih.gov/pubmed/26962864
http://dx.doi.org/10.1371/journal.ppat.1005499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786273/
https://www.ncbi.nlm.nih.gov/pubmed/26962864
http://dx.doi.org/10.1371/journal.ppat.1005499

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