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Stability of Ensemble Models Predicts Productivity of Enzymatic Systems

Stability in a metabolic system may not be obtained if incorrect amounts of enzymes are used. Without stability, some metabolites may accumulate or deplete leading to the irreversible loss of the desired operating point. Even if initial enzyme amounts achieve a stable steady state, changes in enzyme...

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Detalles Bibliográficos
Autores principales: Theisen, Matthew K., Lafontaine Rivera, Jimmy G., Liao, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786283/
https://www.ncbi.nlm.nih.gov/pubmed/26963521
http://dx.doi.org/10.1371/journal.pcbi.1004800