Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin (NPM1) integrates within the nucleolus via a multi-modal mechanism involving multivalent interactions with proteins containing...

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Detalles Bibliográficos
Autores principales: Mitrea, Diana M, Cika, Jaclyn A, Guy, Clifford S, Ban, David, Banerjee, Priya R, Stanley, Christopher B, Nourse, Amanda, Deniz, Ashok A, Kriwacki, Richard W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786410/
https://www.ncbi.nlm.nih.gov/pubmed/26836305
http://dx.doi.org/10.7554/eLife.13571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786410/
https://www.ncbi.nlm.nih.gov/pubmed/26836305
http://dx.doi.org/10.7554/eLife.13571

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