Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex

Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin, a cytotoxic and anti-adipogenic natural produ...

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Detalles Bibliográficos
Autores principales: Carelli, Jordan D, Sethofer, Steven G, Smith, Geoffrey A, Miller, Howard R, Simard, Jillian L, Merrick, William C, Jain, Rishi K, Ross, Nathan T, Taunton, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786417/
https://www.ncbi.nlm.nih.gov/pubmed/26651998
http://dx.doi.org/10.7554/eLife.10222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786417/
https://www.ncbi.nlm.nih.gov/pubmed/26651998
http://dx.doi.org/10.7554/eLife.10222

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