Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer's disease amyloid precursor protein. ADAM10 is als...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuhn, Peer-Hendrik, Colombo, Alessio Vittorio, Schusser, Benjamin, Dreymueller, Daniela, Wetzel, Sebastian, Schepers, Ute, Herber, Julia, Ludwig, Andreas, Kremmer, Elisabeth, Montag, Dirk, Müller, Ulrike, Schweizer, Michaela, Saftig, Paul, Bräse, Stefan, Lichtenthaler, Stefan F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786429/
https://www.ncbi.nlm.nih.gov/pubmed/26802628
http://dx.doi.org/10.7554/eLife.12748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786429/
https://www.ncbi.nlm.nih.gov/pubmed/26802628
http://dx.doi.org/10.7554/eLife.12748

Ejemplares similares