Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

Adolescents are especially prone to drug addiction, but the underlying biological basis of their increased vulnerability remains unknown. We reveal that translational control by phosphorylation of the translation initiation factor eIF2α (p-eIF2α) accounts for adolescent hypersensitivity to cocaine....

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Detalles Bibliográficos
Autores principales: Huang, Wei, Placzek, Andon N, Viana Di Prisco, Gonzalo, Khatiwada, Sanjeev, Sidrauski, Carmela, Krnjević, Krešimir, Walter, Peter, Dani, John A, Costa-Mattioli, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786430/
https://www.ncbi.nlm.nih.gov/pubmed/26928234
http://dx.doi.org/10.7554/eLife.12052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786430/
https://www.ncbi.nlm.nih.gov/pubmed/26928234
http://dx.doi.org/10.7554/eLife.12052

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