Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis

Increased APP (amyloid precursor protein) processing causes β-amyloid (Aβ) accumulation in autosomal dominant Alzheimer's disease (AD), but it is unclear if it also affects sporadic Aβ accumulation. We tested healthy controls and patients with mild cognitive symptoms (N=331) in the BioFINDER st...

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Detalles Bibliográficos
Autores principales: Mattsson, Niklas, Insel, Philip S., Palmqvist, Sebastian, Stomrud, Erik, van Westen, Danielle, Minthon, Lennart, Zetterberg, Henrik, Blennow, Kaj, Hansson, Oskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786682/
https://www.ncbi.nlm.nih.gov/pubmed/26948379
http://dx.doi.org/10.1038/ncomms10918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786682/
https://www.ncbi.nlm.nih.gov/pubmed/26948379
http://dx.doi.org/10.1038/ncomms10918

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