A general approach to visualize protein binding and DNA conformation without protein labelling

Single-molecule manipulation methods, such as magnetic tweezers and flow stretching, generally use the measurement of changes in DNA extension as a proxy for examining interactions between a DNA-binding protein and its substrate. These approaches are unable to directly measure protein–DNA associatio...

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Detalles Bibliográficos
Autores principales: Song, Dan, Graham, Thomas G. W., Loparo, Joseph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786781/
https://www.ncbi.nlm.nih.gov/pubmed/26952553
http://dx.doi.org/10.1038/ncomms10976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786781/
https://www.ncbi.nlm.nih.gov/pubmed/26952553
http://dx.doi.org/10.1038/ncomms10976

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