Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases

The Michael-type addition reaction is widely used in organic synthesis for carbon–carbon bond formation. However, biocatalytic methodologies for this type of reaction are scarce, which is related to the fact that enzymes naturally catalysing carbon–carbon bond-forming Michael-type additions are rare...

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Detalles Bibliográficos
Autores principales: van der Meer, Jan-Ytzen, Poddar, Harshwardhan, Baas, Bert-Jan, Miao, Yufeng, Rahimi, Mehran, Kunzendorf, Andreas, van Merkerk, Ronald, Tepper, Pieter G., Geertsema, Edzard M., Thunnissen, Andy-Mark W. H., Quax, Wim J., Poelarends, Gerrit J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786785/
https://www.ncbi.nlm.nih.gov/pubmed/26952338
http://dx.doi.org/10.1038/ncomms10911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786785/
https://www.ncbi.nlm.nih.gov/pubmed/26952338
http://dx.doi.org/10.1038/ncomms10911

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