Potent and Targeted Activation of Latent HIV-1 Using the CRISPR/dCas9 Activator Complex

HIV-1 provirus integration results in a persistent latently infected reservoir that is recalcitrant to combined antiretroviral therapy (cART) with lifelong treatment being the only option. The “shock and kill” strategy aims to eradicate latent HIV by reactivating proviral gene expression in the cont...

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Detalles Bibliográficos
Autores principales: Saayman, Sheena M, Lazar, Daniel C, Scott, Tristan A, Hart, Jonathan R, Takahashi, Mayumi, Burnett, John C, Planelles, Vicente, Morris, Kevin V, Weinberg, Marc S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786915/
https://www.ncbi.nlm.nih.gov/pubmed/26581162
http://dx.doi.org/10.1038/mt.2015.202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786915/
https://www.ncbi.nlm.nih.gov/pubmed/26581162
http://dx.doi.org/10.1038/mt.2015.202

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