Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain

Angelman syndrome (AS) is a neurological genetic disorder caused by loss of expression of the maternal copy of UBE3A in the brain. Due to brain-specific genetic imprinting at this locus, the paternal UBE3A is silenced by a long antisense transcript. Inhibition of the antisense transcript could lead...

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Detalles Bibliográficos
Autores principales: Bailus, Barbara J, Pyles, Benjamin, McAlister, Michelle M, O'Geen, Henriette, Lockwood, Sarah H, Adams, Alexa N, Nguyen, Jennifer Trang T, Yu, Abigail, Berman, Robert F, Segal, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786922/
https://www.ncbi.nlm.nih.gov/pubmed/26727042
http://dx.doi.org/10.1038/mt.2015.236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786922/
https://www.ncbi.nlm.nih.gov/pubmed/26727042
http://dx.doi.org/10.1038/mt.2015.236

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