CRISPR-Cas9 Can Inhibit HIV-1 Replication but NHEJ Repair Facilitates Virus Escape

Several recent studies demonstrated that the clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonuclease Cas9 can be used for guide RNA (gRNA)-directed, sequence-specific cleavage of HIV proviral DNA in infected cells. We here demonstrate profound inhibition of HIV-1 r...

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Detalles Bibliográficos
Autores principales: Wang, Gang, Zhao, Na, Berkhout, Ben, Das, Atze T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786927/
https://www.ncbi.nlm.nih.gov/pubmed/26796669
http://dx.doi.org/10.1038/mt.2016.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786927/
https://www.ncbi.nlm.nih.gov/pubmed/26796669
http://dx.doi.org/10.1038/mt.2016.24

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