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How compensation breaks down in Parkinson's disease: Insights from modeling of denervated striatum

The bradykinesia and other motor signs of Parkinson's disease (PD) are linked to progressive loss of substantia nigra dopamine (DA) neurons innervating the striatum. However, the emergence of idiopathic PD is likely preceded by a prolonged subclinical phase, which may be masked by a variety of...

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Detalles Bibliográficos
Autores principales: Navntoft, Charlotte Amalie, Dreyer, Jakob Kisbye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787207/
https://www.ncbi.nlm.nih.gov/pubmed/26890687
http://dx.doi.org/10.1002/mds.26579