Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2

Eukaryal translation initiation factor 2B (eIF2B) acts as guanine nucleotide exchange factor (GEF) for eIF2 and forms a central target for pathways regulating global protein synthesis. eIF2B consists of five non-identical subunits (α–ϵ), which assemble into a catalytic subcomplex (γ, ϵ) responsible...

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Detalles Bibliográficos
Autores principales: Kuhle, Bernhard, Eulig, Nora K., Ficner, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787765/
https://www.ncbi.nlm.nih.gov/pubmed/26384431
http://dx.doi.org/10.1093/nar/gkv930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787765/
https://www.ncbi.nlm.nih.gov/pubmed/26384431
http://dx.doi.org/10.1093/nar/gkv930

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