Mechanism of aromatic amine carcinogen bypass by the Y-family polymerase, Dpo4

Bulky DNA damage inhibits DNA synthesis by replicative polymerases and often requires the action of error prone bypass polymerases. The exact mechanism governing adduct-induced mutagenesis and its dependence on the DNA sequence context remains unclear. In this work, we characterize Dpo4 binding conf...

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Detalles Bibliográficos
Autores principales: Brenlla, Alfonso, Rueda, David, Romano, Louis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787768/
https://www.ncbi.nlm.nih.gov/pubmed/26481355
http://dx.doi.org/10.1093/nar/gkv1067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787768/
https://www.ncbi.nlm.nih.gov/pubmed/26481355
http://dx.doi.org/10.1093/nar/gkv1067

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