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Mechanism of aromatic amine carcinogen bypass by the Y-family polymerase, Dpo4
Bulky DNA damage inhibits DNA synthesis by replicative polymerases and often requires the action of error prone bypass polymerases. The exact mechanism governing adduct-induced mutagenesis and its dependence on the DNA sequence context remains unclear. In this work, we characterize Dpo4 binding conf...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787768/ https://www.ncbi.nlm.nih.gov/pubmed/26481355 http://dx.doi.org/10.1093/nar/gkv1067 |