Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation

Unusual DNA/RNA structures of the C9orf72 repeat may participate in repeat expansions or pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia. Expanded repeats are CpG methylated with unknown consequences. Typically, quadruplex structures form by G-rich but not complementary C-r...

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Detalles Bibliográficos
Autores principales: Zamiri, Bita, Mirceta, Mila, Bomsztyk, Karol, Macgregor, Robert B., Pearson, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787773/
https://www.ncbi.nlm.nih.gov/pubmed/26432832
http://dx.doi.org/10.1093/nar/gkv1008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787773/
https://www.ncbi.nlm.nih.gov/pubmed/26432832
http://dx.doi.org/10.1093/nar/gkv1008

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