Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A

Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of aminoacyl-tRNA to the A site, but prevents its subsequent adjustment such that...

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Detalles Bibliográficos
Autores principales: Kaminishi, Tatsuya, Schedlbauer, Andreas, Fabbretti, Attilio, Brandi, Letizia, Ochoa-Lizarralde, Borja, He, Cheng-Guang, Milón, Pohl, Connell, Sean R., Gualerzi, Claudio O., Fucini, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787777/
https://www.ncbi.nlm.nih.gov/pubmed/26464437
http://dx.doi.org/10.1093/nar/gkv975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787777/
https://www.ncbi.nlm.nih.gov/pubmed/26464437
http://dx.doi.org/10.1093/nar/gkv975

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