Structural basis for DNA strand separation by a hexameric replicative helicase

Hexameric helicases are processive DNA unwinding machines but how they engage with a replication fork during unwinding is unknown. Using electron microscopy and single particle analysis we determined structures of the intact hexameric helicase E1 from papillomavirus and two complexes of E1 bound to...

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Detalles Bibliográficos
Autores principales: Chaban, Yuriy, Stead, Jonathan A., Ryzhenkova, Ksenia, Whelan, Fiona, Lamber, Ekaterina P., Antson, Alfred, Sanders, Cyril M., Orlova, Elena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787811/
https://www.ncbi.nlm.nih.gov/pubmed/26240379
http://dx.doi.org/10.1093/nar/gkv778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787811/
https://www.ncbi.nlm.nih.gov/pubmed/26240379
http://dx.doi.org/10.1093/nar/gkv778

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