Solution structure of a DNA quadruplex containing ALS and FTD related GGGGCC repeat stabilized by 8-bromodeoxyguanosine substitution

A prolonged expansion of GGGGCC repeat within non-coding region of C9orf72 gene has been identified as the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which are devastating neurodegenerative disorders. Formation of unusual secondary structures...

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Detalles Bibliográficos
Autores principales: Brčić, Jasna, Plavec, Janez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787828/
https://www.ncbi.nlm.nih.gov/pubmed/26253741
http://dx.doi.org/10.1093/nar/gkv815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787828/
https://www.ncbi.nlm.nih.gov/pubmed/26253741
http://dx.doi.org/10.1093/nar/gkv815

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