Dynamic Modelling Reveals ‘Hotspots’ on the Pathway to Enzyme-Substrate Complex Formation

Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step in the diaminopimelate pathway of bacteria, yielding amino acids required for cell wall and protein biosyntheses. The essentiality of the enzyme to bacteria, coupled with its absence in humans, validates DHDPS as an antibacteria...

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Detalles Bibliográficos
Autores principales: Gordon, Shane E., Weber, Daniel K., Downton, Matthew T., Wagner, John, Perugini, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788353/
https://www.ncbi.nlm.nih.gov/pubmed/26967332
http://dx.doi.org/10.1371/journal.pcbi.1004811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788353/
https://www.ncbi.nlm.nih.gov/pubmed/26967332
http://dx.doi.org/10.1371/journal.pcbi.1004811

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