Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential

WT1(126) (RMFPNAPYL) is a human leukocyte antigen-A2 (HLA-A2)-restricted peptide derived from Wilms tumor protein 1 (WT1), which is widely expressed in a broad spectrum of leukemias, lymphomas and solid tumors. A novel T-cell-receptor (TCR)-like single-chain variable fragment (scFv) antibody specifi...

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Detalles Bibliográficos
Autores principales: Zhao, Q, Ahmed, M, Tassev, D V, Hasan, A, Kuo, T-Y, Guo, H-F, O'Reilly, R J, Cheung, N-K V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788467/
https://www.ncbi.nlm.nih.gov/pubmed/25987253
http://dx.doi.org/10.1038/leu.2015.125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788467/
https://www.ncbi.nlm.nih.gov/pubmed/25987253
http://dx.doi.org/10.1038/leu.2015.125

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