Cargando…

Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential

WT1(126) (RMFPNAPYL) is a human leukocyte antigen-A2 (HLA-A2)-restricted peptide derived from Wilms tumor protein 1 (WT1), which is widely expressed in a broad spectrum of leukemias, lymphomas and solid tumors. A novel T-cell-receptor (TCR)-like single-chain variable fragment (scFv) antibody specifi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Q, Ahmed, M, Tassev, D V, Hasan, A, Kuo, T-Y, Guo, H-F, O'Reilly, R J, Cheung, N-K V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788467/ https://www.ncbi.nlm.nih.gov/pubmed/25987253 http://dx.doi.org/10.1038/leu.2015.125

Ejemplares similares

Toll-like receptor 9 antagonizes antibody affinity maturation
por: Akkaya, Munir, et al.
Publicado: (2018)

Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo
por: Cheung, Nai-Kong V., et al.
Publicado: (2012)

Peptide Affinity Chromatography Applied to Therapeutic Antibodies Purification
por: Barredo-Vacchelli, Gabriela R., et al.
Publicado: (2021)

Affinity maturation generates greatly improved xyloglucan-specific carbohydrate binding modules
por: von Schantz, Laura, et al.
Publicado: (2009)

Affinity maturation of TCR-like antibodies using phage display guided by structural modeling
por: Frick, Rahel, et al.
Publicado: (2022)

On the Rapid Calculation of Binding Affinities for Antigen and Antibody Design and Affinity Maturation Simulations
por: Conti, Simone, et al.
Publicado: (2022)

Antibody Affinity Maturation in Fishes—Our Current Understanding
por: Magor, Brad G.
Publicado: (2015)

Local and Global Rigidification Upon Antibody Affinity Maturation
por: Fernández-Quintero, Monica L., et al.
Publicado: (2020)

Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence–based affinity maturation
por: Kielczewska, Agnieszka, et al.
Publicado: (2021)

Affinity Maturation of a T-Cell Receptor-Like Antibody Specific for a Cytomegalovirus pp65-Derived Peptide Presented by HLA-A*02:01
por: Lee, Se-Young, et al.
Publicado: (2021)

Shark Antibody Variable Domains Rigidify Upon Affinity Maturation—Understanding the Potential of Shark Immunoglobulins as Therapeutics
por: Fernández-Quintero, Monica L., et al.
Publicado: (2021)

Ofatumumab Monoclonal Antibody Affinity Maturation Through in silico Modeling
por: Payandeh, Zahra, et al.
Publicado: (2018)

The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins
por: Salomonsson, Emma, et al.
Publicado: (2011)

A Case of Wilms Tumor in a Primary Adrenal Mature Teratoma
por: Alahdal, Arwa, et al.
Publicado: (2023)

An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with in vivo therapeutic potency
por: Kotaki, Tomohiro, et al.
Publicado: (2021)

Mapping protein interactions by combining antibody affinity maturation and mass spectrometry
por: Dyson, Michael R., et al.
Publicado: (2011)

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies
por: Briney, Bryan, et al.
Publicado: (2016)

In vitro affinity maturation of antibody against membrane-bound GPCR molecules
por: Wang, Jie, et al.
Publicado: (2019)

Affinity maturation: highlights in the application of in vitro strategies for the directed evolution of antibodies
por: Chan, Denice T.Y., et al.
Publicado: (2021)

Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation Sequencing
por: Mishra, Arjun K., et al.
Publicado: (2018)

Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturation
por: Silver, Jared, et al.
Publicado: (2018)

Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis
por: Tiller, Kathryn E., et al.
Publicado: (2017)

Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR
por: Simons, Jan Fredrik, et al.
Publicado: (2020)

Computational-Driven Epitope Verification and Affinity Maturation of TLR4-Targeting Antibodies
por: Ahmad, Bilal, et al.
Publicado: (2021)

Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV
por: Conti, Simone, et al.
Publicado: (2022)

Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity
por: Desai, Alec A., et al.
Publicado: (2021)

Simultaneous Maturation of Single Chain Antibody Stability and Affinity by CHO Cell Display
por: Luo, Ruiqi, et al.
Publicado: (2022)

In vivo affinity maturation of murine B cells reprogrammed to express human antibodies
por: Yin, Yiming, et al.
Publicado: (2023)

Insights into the Mechanisms of Antibody-Affinity Maturation and the Generation of the Memory B-Cell Compartment Using Genetically Altered Mice
por: Vora, Kalpit A., et al.
Publicado: (1998)

MAPs: a database of modular antibody parts for predicting tertiary structures and designing affinity matured antibodies
por: Pantazes, Robert J, et al.
Publicado: (2013)

Molecular Biology of Wilm's Tumour
por: Shaw, A. P. W., et al.
Publicado: (1988)

The influence of antibody fragment format on phage display based affinity maturation of IgG
por: Steinwand, Miriam, et al.
Publicado: (2014)

Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies
por: Wang, Shenshen, et al.
Publicado: (2015)

Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity Maturation
por: Lim, Chia Chiu, et al.
Publicado: (2019)

Wilms' Tumour
por: Pearson, D.
Publicado: (1976)

Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation
por: Chan, Denice T. Y., et al.
Publicado: (2020)

Mobile Affinity Selection Chromatography Analysis of Therapeutic Monoclonal Antibodies
por: Narsimhan, Meena L., et al.
Publicado: (2023)

Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer
por: Ko, Bong-Kook, et al.
Publicado: (2015)

Adult Wilms tumor: Case report
por: Morabito, V., et al.
Publicado: (2014)

Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein
por: Pavoni, Emiliano, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_pgvuptped8brohh80r2bdsh856