Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

Patients with an HNF1B(S148L/+) mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully recapitulate MODY5. Here, we differentiated MODY5 human-induced pluripotent stem ce...

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Detalles Bibliográficos
Autores principales: Teo, Adrian Kee Keong, Lau, Hwee Hui, Valdez, Ivan Achel, Dirice, Ercument, Tjora, Erling, Raeder, Helge, Kulkarni, Rohit N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788763/
https://www.ncbi.nlm.nih.gov/pubmed/26876668
http://dx.doi.org/10.1016/j.stemcr.2016.01.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788763/
https://www.ncbi.nlm.nih.gov/pubmed/26876668
http://dx.doi.org/10.1016/j.stemcr.2016.01.007

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