Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity

A widespread decrease of mature microRNAs is often observed in human malignancies giving them potential to act as tumor suppressors. Thus, microRNAs may be potential targets for cancer therapy. The global miRNA deregulation is often the result of defects in the miRNA biogenesis pathway, such as geno...

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Detalles Bibliográficos
Autores principales: Gurtner, Aymone, Falcone, Emmanuela, Garibaldi, Francesca, Piaggio, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789259/
https://www.ncbi.nlm.nih.gov/pubmed/26971015
http://dx.doi.org/10.1186/s13046-016-0319-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789259/
https://www.ncbi.nlm.nih.gov/pubmed/26971015
http://dx.doi.org/10.1186/s13046-016-0319-x

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