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Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn’s disease-associated fibrosis

BACKGROUND: Fibrosis of the intestine is a common and poorly understood complication of Crohn’s disease (CD) characterized by excessive deposition of extracellular matrix and accompanied by narrowing and obstruction of the gut lumen. Defining the molecular characteristics of this fibrotic disorder i...

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Detalles Bibliográficos
Autores principales: Sadler, Tammy, Bhasin, Jeffrey M., Xu, Yaomin, Barnholz-Sloan, Jill, Chen, Yanwen, Ting, Angela H., Stylianou, Eleni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789277/
https://www.ncbi.nlm.nih.gov/pubmed/26973718
http://dx.doi.org/10.1186/s13148-016-0193-6