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Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia
BACKGROUND: Mixed lineage leukemia (MLL) gene translocations are found in ~75 % infant and 10 % adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a drug target for this subtype of leukemia. More studies using potent LSD1 inhibitor...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789278/ https://www.ncbi.nlm.nih.gov/pubmed/26970896 http://dx.doi.org/10.1186/s13045-016-0252-7 |