The MLN4924 inhibitor exerts a neuroprotective effect against oxidative stress injury via Nrf2 protein accumulation

It was explored the cytoprotective and antioxidant effect of MLN4924, a specific inhibitor of Nedd8-activating enzyme (NAE), against hydrogen peroxide (H(2)O(2))-induced damage in cerebellar granule neurons (CGNs). Primary cultures of CGNs were exposed to H(2)O(2) after preincubation with MLN4924. T...

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Detalles Bibliográficos
Autores principales: Andérica-Romero, Ana Cristina, Hernández-Damián, Jacqueline, Vázquez-Cervantes, Gustavo Ignacio, Torres, Ismael, Pedraza-Chaverri, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789348/
https://www.ncbi.nlm.nih.gov/pubmed/26966893
http://dx.doi.org/10.1016/j.redox.2016.02.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789348/
https://www.ncbi.nlm.nih.gov/pubmed/26966893
http://dx.doi.org/10.1016/j.redox.2016.02.008

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