Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease: Consequences for Epigenetic Regulation of rDNA and Cognition

Synaptic dysfunction is thought to play a major role in memory impairment in Alzheimer's disease (AD). PARP-1 has been identified as an epigenetic regulator of plasticity and memory. Thus, we hypothesize that PARP-1 may be altered in postmortem hippocampus of individuals with AD compared to age...

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Detalles Bibliográficos
Autores principales: Zeng, Jianying, Libien, Jenny, Shaik, Fatima, Wolk, Jason, Hernández, A. Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789469/
https://www.ncbi.nlm.nih.gov/pubmed/27034851
http://dx.doi.org/10.1155/2016/8987928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789469/
https://www.ncbi.nlm.nih.gov/pubmed/27034851
http://dx.doi.org/10.1155/2016/8987928

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