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Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease: Consequences for Epigenetic Regulation of rDNA and Cognition

Synaptic dysfunction is thought to play a major role in memory impairment in Alzheimer's disease (AD). PARP-1 has been identified as an epigenetic regulator of plasticity and memory. Thus, we hypothesize that PARP-1 may be altered in postmortem hippocampus of individuals with AD compared to age...

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Detalles Bibliográficos
Autores principales:	Zeng, Jianying, Libien, Jenny, Shaik, Fatima, Wolk, Jason, Hernández, A. Iván
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789469/ https://www.ncbi.nlm.nih.gov/pubmed/27034851 http://dx.doi.org/10.1155/2016/8987928

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